|Trade names||Maxzide, Dyazide, others|
Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a combination medication of hydrochlorothiazide and triamterene. It is used to treat high blood pressure and swelling. Specifically it is used in those who develop low blood potassium when on only hydrochlorothiazide. It is taken by mouth.
Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps. Other serious side effects may include high blood potassium. Use in pregnancy and breastfeeding is not generally recommended. Use in those with significant kidney problems is not recommended. It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.
The combination was approved for medical use in the United States in 1965. A month supply in the United Kingdom costs the NHS about 0.95 £ per month as of 2019. In the United States the wholesale cost of this amount is about 3.90 USD. In 2016 it was the 60th most prescribed medication in the United States with more than 12 million prescriptions.
- British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
- "Triamterene and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 5 March 2019.
- "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.